Peptides for Weight Loss & Metabolic Health
Peptides studied for weight management, metabolic function, and body composition.
Important
This page lists peptides that have been studied in the context of weight loss & metabolic health research. Inclusion does not mean a peptide is safe, effective, approved, or recommended.
Do not use this page to make health decisions. Always consult a licensed healthcare provider.
28 peptides
Dasiglucagon (Zegalogue)
FDA ApprovedAn FDA-approved emergency rescue medication (Zegalogue) for severe low blood sugar in children (age 6 and older) and adults with diabetes. It works...
Dulaglutide (Trulicity)
FDA ApprovedAn FDA-approved once-weekly injection (Trulicity) for type 2 diabetes that controls blood sugar and also reduces the risk of heart attack and stroke...
Exenatide (Byetta, Bydureon)
FDA ApprovedAn FDA-approved injectable medication (Byetta, Bydureon BCise) for type 2 diabetes, originally derived from a protein found in Gila monster saliva,...
Lanreotide (Somatuline Depot)
FDA ApprovedAn FDA-approved monthly injection (Somatuline Depot) that blocks the overproduction of certain hormones, used for acromegaly (a condition caused by...
Liraglutide (Victoza, Saxenda)
FDA ApprovedAn FDA-approved once-daily injection that mimics a natural gut hormone to control blood sugar in type 2 diabetes (Victoza) and promote significant...
Lixisenatide (Adlyxin)
FDA ApprovedAn FDA-approved once-daily injection for type 2 diabetes that mimics a natural gut hormone to lower blood sugar, particularly after meals, by slowing...
Octreotide (Sandostatin, Sandostatin LAR, Mycapssa, Bynfezia Pen)
FDA ApprovedAn FDA-approved injection (Sandostatin) that helps control the overproduction of certain hormones in the body. It is used to treat acromegaly (excess...
Pramlintide (Symlin)
FDA ApprovedAn FDA-approved injectable medication (Symlin) taken at mealtimes alongside insulin by people with type 1 or type 2 diabetes. It mimics a natural...
Semaglutide (Ozempic, Wegovy, Rybelsus)
FDA ApprovedAn FDA-approved medication sold as Ozempic (for type 2 diabetes) and Wegovy (for weight management), given as a once-weekly injection or a daily oral...
Setmelanotide (Imcivree)
FDA ApprovedAn FDA-approved daily injection (IMCIVREE) for rare forms of severe obesity caused by specific genetic conditions that disrupt the brain's...
Teduglutide (Gattex / Revestive)
FDA ApprovedAn FDA-approved injection (Gattex in the US, Revestive in Europe) for adults and children as young as 1 year old with short bowel syndrome who depend...
Tesamorelin (Egrifta)
FDA ApprovedAn FDA-approved daily injection (Egrifta, Egrifta SV) for HIV-positive adults who develop excess belly fat as a side effect of their HIV medications....
Tirzepatide (Mounjaro, Zepbound)
FDA ApprovedAn FDA-approved once-weekly injection (Mounjaro for type 2 diabetes, Zepbound for weight loss) that activates two natural gut hormone pathways at...
Vasopressin (Vasostrict, Pitressin; also known as AVP, ADH)
FDA ApprovedAn FDA-approved emergency hospital medication (Vasostrict) used for dangerously low blood pressure and during cardiac arrest. It works by tightening...
Cagrilintide
Late-Stage ClinicalAn investigational once-weekly injection that mimics amylin (a natural hormone your body uses to control appetite), being developed for weight loss...
CagriSema
Late-Stage ClinicalAn investigational once-weekly combination injection that pairs two appetite-controlling medications to produce powerful weight loss. In a major...
Ecnoglutide
Late-Stage ClinicalA once-weekly injection approved in China for type 2 diabetes and obesity that works by mimicking a natural gut hormone to lower blood sugar and...
Intranasal Insulin
Late-Stage ClinicalRegular human insulin delivered via nasal spray to bypass the blood-brain barrier, targeting central insulin receptors for cognitive enhancement,...
Retatrutide (LY3437943)
Late-Stage ClinicalAn investigational once-weekly injection that works on three different appetite and metabolism pathways at once, producing some of the most...
Survodutide (BI 456906)
Late-Stage ClinicalAn investigational once-weekly injection being developed for obesity and MASH (a serious form of fatty liver disease that can lead to liver damage)....
GHRP-2
Early ClinicalA lab-made peptide that triggers growth hormone release from the pituitary gland (a small gland in the brain) by working like ghrelin, the body's...
GHRP-6
Early ClinicalA synthetic peptide that mimics ghrelin (the body's hunger hormone) to stimulate the natural release of growth hormone, which has been shown...
MK-677 (Ibutamoren)
Early ClinicalAn oral daily compound (ibutamoren) that mimics ghrelin (the body's hunger hormone) to raise growth hormone levels, studied in people for building...
Sermorelin (Geref)
Early ClinicalA synthetic peptide that stimulates the pituitary gland (a small gland in the brain) to release growth hormone naturally by mimicking the body's own...
Adipotide
Limited HumanAn experimental compound studied in animal research for fat reduction by targeting the blood supply to fat tissue. A human safety trial was started...
CJC-1295
Limited HumanA lab-made peptide that triggers the pituitary gland (a small gland in the brain that controls hormone production) to release growth hormone over...
Ipamorelin
Limited HumanA synthetic peptide that stimulates growth hormone release from the pituitary gland (a small gland in the brain) without significantly raising stress...
Humanin
PreclinicalA tiny natural peptide produced by mitochondria (the energy-producing parts of your cells), first discovered in 2001 in Alzheimer's disease research...