Peptides for Neurological Health
Peptides investigated for neuroprotection, cognitive function, and neurological conditions including stroke, TBI, and neurodegeneration.
18 peptides
Lanreotide (Somatuline Depot)
FDA ApprovedAn FDA-approved long-acting somatostatin analog (brand: Somatuline Depot) indicated for acromegaly, gastroenteropancreatic neuroendocrine tumors...
Octreotide (Sandostatin, Sandostatin LAR, Mycapssa, Bynfezia Pen)
FDA ApprovedOctreotide is an FDA-approved synthetic somatostatin analogue that suppresses growth hormone, IGF-1, and gastrointestinal hormones, used primarily...
Cerebrolysin
Strong EvidenceCerebrolysin is an injectable porcine brain-derived peptide preparation with neurotrophic, neuroprotective, and neuroplasticity-enhancing properties,...
NSI-189 (also known as Amdiglurax, ALTO-100, ALTO-300)
Moderate EvidenceNSI-189 is a novel small molecule neurogenic compound developed for major depressive disorder (MDD) that stimulates hippocampal neurogenesis...
Pinealon
Moderate EvidenceA synthetic neuroprotective tripeptide (Glu-Asp-Arg) with limited human and multiple preclinical evidence for reducing oxidative stress and apoptosis...
Sermorelin (Geref)
Moderate EvidenceA synthetic 29-amino acid analog of endogenous human GHRH that stimulates pituitary growth hormone release. Previously FDA-approved for pediatric GH...
VIP (Vasoactive Intestinal Peptide); Aviptadil (synthetic VIP); ZYESAMI; RLF-100
Moderate EvidenceVIP is a 28-amino acid endogenous neuropeptide and high-affinity agonist at VPAC1 (EC50 0.02-0.03 nM) and VPAC2 (EC50 0.05-0.087 nM) receptors. Acts...
BPC-157 (Pentadecapeptide)
Limited Human DataBPC-157 is a synthetic 15-amino-acid peptide derived from human gastric juice protein BPC that demonstrates broad cytoprotective, pro-angiogenic, and...
PACAP-38
Limited Human DataPACAP-38 is an endogenous 38-amino-acid neuropeptide that activates PAC1, VPAC1, and VPAC2 receptors, playing a central role in migraine...
Selank
Limited Human DataSelank is a synthetic heptapeptide analog of the endogenous immunomodulatory peptide tuftsin, developed in Russia as an anxiolytic and nootropic...
Semax
Limited Human DataSemax is a synthetic heptapeptide analog of ACTH(4-10) developed in Russia, used clinically as an intranasal neuroprotective and nootropic agent...
Cortagen
Animal Studies OnlyA synthetic tetrapeptide (Ala-Glu-Asp-Pro) derived from Cortexin brain extract, studied primarily in preclinical models for nerve regeneration,...
Dihexa
Animal Studies OnlyDihexa is an orally active, blood-brain barrier-permeant angiotensin IV analog that promotes synaptogenesis and cognitive improvement in preclinical...
Humanin
Animal Studies OnlyA 24-amino acid mitochondrial-derived peptide (MDP) first discovered in 2001 from surviving neurons of Alzheimer's disease brain tissue, with...
N-Acetyl Selank Amidate
Animal Studies OnlyN-Acetyl Selank Amidate is a stabilized synthetic derivative of Selank (TP-7), modified with N-terminal acetylation and C-terminal amidation to...
NA-Semax Amidate
Animal Studies OnlyNA-Semax Amidate is a doubly modified (N-acetylated, C-amidated) analog of the Russian neuropeptide Semax (ACTH 4-10 fragment), designed for enhanced...
P21 (P021)
Animal Studies OnlyP21 (P021) is a synthetic tetrapeptide mimetic of ciliary neurotrophic factor (CNTF) designed to promote neurogenesis, enhance BDNF expression, and...
PE-22-28
Animal Studies OnlyPE-22-28 is a synthetic heptapeptide analog of spadin that potently and selectively inhibits the TREK-1 two-pore domain potassium channel (IC50 0.12...